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This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. Europe PMC is an archive of life sciences journal literature. The major channels include ABC News, CBS News, Cheddar News, WWE Network, The Weather Channel, and Fubo Sports. In parallel with the contraction of the cLP Treg cell population in Foxp3 EGFPcre Myd88 ฮ/ฮ mice, there was expansion of IL-17-expressing cLP CD4 + Tconv cells (Figures 2 J and 2K). MyD88 is an adapter protein that is involved in Toll-like receptor (TLR)- and interleukin-1 receptor (IL-1R)-induced activation of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK). Weitz,* David Gate,* Kavon Rezai-Zadeh,y and Terrence Town* From the Zilkha Neurogenetic Institute,* Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern. Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). 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